Connectome: How the Brain's Wiring Makes Us Who We Are
Seung (Sebastian)
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Inside Cover Blurb

  1. We know that each of us is unique, but science has struggled to pinpoint where, precisely, our uniqueness resides. Is it in our genes? The structure of our brains? Our genome may determine our eye color and even aspects of our personality. But our friendships, failures, and passions also shape who we are. The question is: how?
  2. Sebastian Seung, a dynamic professor at MIT, is on a quest to discover the biological basis of identity. He believes it lies in the pattern of connections between the brain’s neurons, which change slowly over time as we learn and grow. The connectome, as it’s called, is where our genetic inheritance intersects with our life experience. It’s where nature meets nurture.
    Seung introduces us to the dedicated researchers who are mapping the brain’s connections, neuron by neuron, synapse by synapse. It is a monumental undertaking — the scientific equivalent of climbing Mount Everest — but if they succeed, it could reveal the basis of personality, intelligence, memory, and perhaps even mental disorders. Many scientists speculate that people with anorexia, autism, and schizophrenia are "wired differently," but nobody knows for sure. The brain’s wiring has never been clearly seen.
  3. In sparklingly clear prose, Seung reveals the amazing technological advances that will soon help us map connectomes. He also examines the evidence that these maps will someday allow humans to "upload1" their minds into computers, achieving a kind of immortality.
  4. Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and technological vision for at last understanding what makes us who we are. Welcome to the future of neuroscience.
  5. Sebastian Seung is Professor of Computational Neuroscience and Physics at MIT and Investigator at the Howard Hughes Medical Institute. He has made important advances in artificial intelligence and neuroscience. His research has been published in leading scientific journals and also featured in the New York Times, Technology Review, and the Economist.
    Connectome: The Book

Cover Affidavits
  1. “In Connectome, Sebastian Seung reminds us that the human brain has contemplated itself for centuries. This is an important book, full of refreshingly new science and engaging history, about the essential quest to understand ourselves.”
    → Phillip A. Sharp. MIT. 1993 Nobel Prize in Physiology or Medicine
  2. “A landmark work, gorgeously written. No other researcher has travelled as deeply into the brain forest and emerged to share its secrets.”
    David Eagleman, author of Incognito and Sum
  3. “Connectomics is emerging as a crucial and exhilarating field of study. Sebastian Seung takes you by the hand and shows you why. Connectome is a page-turner — a book that should be read by anyone who lays claim to be thinking about the nature of life.”
    Michael S. Gazzaniga, University of California at Santa Barbara, author of Human and Who’s in Charge?
  4. “Sebastian Seung scales the heights of neuroscience and casts his brilliant eye around, describing the landscape of its past and boldly envisioning a future when we may understand our own brains and thus ourselves.”
    → Kenneth Blum, executive director, Center for Brain Science, Harvard University
  5. “Sebastian Seung can do it all. He’s widely recognized as a superb physicist, a whiz with computers, and a path-breaking neuroscientist. Connectome shows that he’s also a terrific writer, as inspiring as he is clear and good-humored.”
    → Steven Strogatz, Cornell University, author of Sync

  1. Does Size Matter?
    1. Genius and Madness – 3
    2. Border Disputes – 22
  2. Connectionism
    1. No Neuron Is an Island – 39
    2. Neurons All the Way Down – 60
    3. The Assembly of Memories – 76
  3. Nature and Nurture
    1. The Forestry of the Genes – 99
    2. Renewing Our Potential – 116
  4. Connectomics
    1. Seeing Is Believing – 137
    2. Following the Trail – 155
    3. Carving – 170
    4. Codebreaking – 185
    5. Comparing – 201
    6. Changing – 216
  5. Beyond Humanity
    1. To Freeze or to Pickle? – 233
    2. Save As …. 254
      Epilogue – 274
      Acknowledgements – 277
      Notes – 279
      References – 314
      Figure Credits – 335
      Index – 337

Book Comment

Houghton Mifflin Harcourt (7 Feb. 2012). Hardback.

Text Colour Conventions (see disclaimer)
  1. Blue: Text by me; © Theo Todman, 2023
  2. Mauve: Text by correspondent(s) or other author(s); © the author(s)

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